Fr. Joseph Strub and the Holy Ghost Fathers founded Duquesne University, then known as The Pittsburgh Catholic College of the Holy Ghost in October 1878. It received its state charter in 1882 and in 1885, the school relocated from a rented space on Downtown Pittsburgh to Bluff, where it still stand up to this day. It became a university in May 1911 and was subsequently named Duquesne University of the Holy Ghost. Three years later, Duquesne established its own graduate school.

Duquesne offers online degree courses in Education, Music, Nursing, Leadership and Professional Advancement and Science. All of these courses, with the exception of Nursing, can be completed online. Students under the Nursing programs can complete their coursework online but will need to schedule visits to campus at Pittsburgh in order to demonstrate their practical abilities.

Due to the variety of courses offered at Duquesne, the University does not have standard admission requirements, and are course and level specific. International students may be required to submit additional documents in support of their application. For information, contact the Duquesne University Admissions Office.

Tuition fees, as with admission requirements are also program-specific. Tuition for most programs range from roughly $25,500.00 to $36,500.00 for two semesters. The Nursing degree program costs about $38,000 and this covers three semesters. Tuition fees do not include any incidental expenses such as uniform, books or laboratory fees. To reduce financial strain, financial aid in the form of federal grants, private scholarships and grants, and student loans are available to eligible students. Special tuition rates apply to students who are on active military duty.

The Middle States Association for Colleges and Schools accredits Duquesne University and Duquesne programs are accredited and recognised by industry-related organizations as well.